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Carbohydrate Restriction as an Adjunct Treatment for Hypothyroidism

One of the functions of T3, the active thyroid hormone, is metabolizing blood sugar. Other things equal, the higher the carbohydrate content of a diet the higher the average levels of blood sugar.

Sure enough, the isocaloric addition of carbohydrate to a diet elevates blood levels of T3.

This is not good news.

While adding carbohydrate to a diet increases blood levels of T3, it does not also increase basal metabolism. This suggests that the additional T3 is used exclusively to metabolize higher levels of blood sugar.

The implications for hypothyroidism should be obvious: The smaller the amount of T3 required to process blood sugar, the greater the amount available to perform more important metabolic functions.

It follows that if high-carbohydrate diets require higher levels of thyroid hormones, they also require higher levels of their dietary precursors, especially iodine. A persuasive case has already been made that, perhaps in most instances, a high level of dietary carbohydrate, not a lack of iodine in the environment, causes iodine-deficiency diseases.

Hypothyroidism is a distressingly common condition, one from which I suffer myself. My diet includes sufficient amounts of the dietary precursors of thyroid hormones, avoids goitrogens (substances in food that inhibit the production of thyroid hormones) and restricts carbohydrate.

References

1. Colorado State Online Textbooks: Mechanism of Action and Physiologic Effects of Thyroid Hormones

“Thyroid hormones stimulate almost all aspects of carbohydrate metabolism, including enhancement of insulin-dependent entry of glucose into cells …”

2. Kim, et al: A hypothesis of synergism: the interrelationship of T3 and insulin to disturbances in metabolic homeostasis; Med Hypotheses, 2002 Dec;59(6):660-6.

“In summary, the synergism between T3 and insulin appears to be responsible for the expression of the enzymes required for the entire process of metabolism of glucose…”

3. Spaulding, et al: Effect of caloric restriction and dietary composition of serum T3 and reverse T3 in man; Journal of Clinical Endocrinology & Metabolism, Jan, 1976; 42 (1): 197–200

“We conclude that dietary carbohydrate is an important regulatory factor in T3 production in man.”

4. Danforth, et al: Dietary-induced Alterations in Thyroid Hormone Metabolism during Overnutrition, Clin Invest. 1979 November; 64(5): 1336–1347

“During the weight-maintenance phases of the long-term overfeeding studies, concentrations of T3 were increased when carbohydrate was isocalorically substituted for fat in the diet.”

5. Bisschop PH, et al: Isocaloric carbohydrate deprivation induces protein catabolism despite a low T3-syndrome in healthy men; Clinical Endocrinology, 2001; 54: 75-80

“…dietary carbohydrate content did not influence resting energy expenditure.”

6. Kopp W.: Nutrition, evolution and thyroid hormone levels – a link to iodine deficiency disorders?; Med Hypotheses. 2004;62(6):871-5.

Abstract: An increased iodine requirement as a result of significant changes in human nutrition rather than a decreased environmental iodine supply is suggested to represent the main cause of the iodine deficiency disorders (IDD). The pathomechanism proposed is based on the fact that serum concentrations of thyroid hormones, especially of trijodothyronine (T3), are dependent on the amount of dietary carbohydrate. High-carbohydrate diets are associated with significantly higher serum T3 concentrations, compared with very low-carbohydrate diets. While our Paleolithic ancestors subsisted on a very low carbohydrate/high protein diet, the agricultural revolution about 10,000 years ago brought about a significant increase in dietary carbohydrate. These nutritional changes have increased T3 levels significantly. Higher T3 levels are associated with an enhanced T3 production and an increased iodine requirement. The higher iodine requirement exceeds the availability of iodine from environmental sources in many regions of the world, resulting in the development of IDD.

Low-Carb Diets and T3: A False Alarm

Prologue

Carbohydrate-restricted diets have come under fire recently over concerns that their association with reduced levels of the active thyroid hormone (T3) might cause the symptoms of hypothyroidism. I will argue that those concerns are unfounded.

There’s no shortage of evidence that, when calories are held constant, blood serum levels of T3 fall in concert with decreases in dietary carbohydrate, and zero-carb diets result in levels of T3 similar to fasting.

There is, on the other hand, no evidence that low-carb or ketogenic diets actually cause any symptom of inadequate thyroid hormone. Indeed, the evidence we do have shows that the primary function of T3, regulating basal metabolism, is unaffected by the amount of carbohydrate in a diet, and suggests that lower levels of T3 associated with low-carb diets are the result of a reduced need to metabolise glucose.

A (Very) Brief Introduction to Thyroid Hormones

Thyroid hormone blood serum levels are controlled by the hypothalamic-pituitary-thyroid (HPT) axis. The hypothalamus secretes thyrotropin-releasing hormone (TRH), which stimulates the pituitary gland to release thyroid stimulating hormone (TSH), which in turn causes the thyroid to release its hormones into the bloodstream.

The thyroid gland produces two hormones, thyroxine (T4) and triiodothyronine (T3), in a ratio of roughly five to one. Both T3 and T4 are either “bound” (in a protein molecule) or “free”, and only the free versions are biologically available. Free T4 is converted to T3 or reverse-T3 (rT3). Free T3 is the active thyroid hormone, while reverse-T3 is either inactive or binds to T3 receptors and inhibits the action of free T3.

Lab tests can measure blood serum levels of TRH, TSH, total T4, total T3, free T4, free T3 and reverse-T3, as well as other markers of thyroid activity.

Hypothyroidism(s)

“Primary” hypothyroidism is caused by the failure of the thyroid gland to produce sufficient thyroid hormones. “Secondary” hypothyroidism is caused by the failure of pituitary or hypothalamus to produce sufficient stimulating hormones.

The symptoms of hypothyroidism include: lowered basal metabolism, fatigue, sluggishness, weakness, cold intolerance, constipation, dry skin, puffy face, hoarse voice, elevated cholesterol, unintentional weight gain, aches and pains, heavier than normal menstrual periods, brittle hair and fingernails, and depression.

In the lab, TSH is elevated and free T4 is low. Levels of free T3 may be normal or low.

“Subclinical” hypothyroidism is characterized by elevated TSH and normal T4, without symptoms.

Low T3 Syndrome

Low T3 syndrome, also known as “euthyroid sick syndrome” (ESS) or “nonthyroidal illness syndrome” (NTIS), is a condition in which thyroid function remains intact but the conversion from T4 to T3 is reduced.

Low T3 syndrome can have other causes, but it is most often found in hospital wards in patients who are ill or recovering from surgery. Whether low T3 syndrome is an adaptive response to stress or a pathology is controversial, as is treatment.

Low T3 syndrome varies in severity depending on the severity of the illness or stress. In “mild” low T3 syndrome, levels of TSH and T4 remain within the normal range, while T3 falls and reverse-T3 rises. In “moderate” low T3 syndrome, TSH is rising and T4 falling, but still within the normal range. In “severe” low T3 syndrome, all thyroid hormones are outside the normal range.

20120413-102345.jpgImage: Medscape Reference

Mild low T3 syndrome has no overt symptoms, and any attempt at diagnosis by symptoms that may be associated with the moderate or severe forms is confounded by the underlying illness or stress. The diagnosis of low T3 syndrome is made exclusively in the laboratory, when levels of T3 and reverse-T3 are found to be outside the normal range.

Low T3 syndrome can exacerbate pre-existing thyroid disease (undiagnosed hypothyroidism or subclinical hypothyroidism).

The Argument From Lack of Evidence

Modern versions of low-carb diets have been around since the early 1970′s, and the relationship between dietary carbohydrate and the active thyroid hormone emerged not much later. Nevertheless, in the popular and scientific articles that raised concerns about the safety of low-carb diets, references to the symptoms of hypothyroidism are conspicuous only by their absence.

Ketogenic diets that restrict carbohydrates, calories, and fluid have been used to treat refractory epilepsy, mostly in children, since 1921. Those diets have been studied extensively since that time. The list of possible side effects has grown quite long, but the symptoms of hypothyroidism are not among them.

The relationship between carbohydrate-restriction and reduced levels of T3 was established more than thirty years ago. To this day, there isn’t a single piece of clinical evidence that carbohydrate-restriction alone causes any symptom of hypothyroidism.

The Argument from Basal Metabolism

Low basal metabolism and the symptoms associated with it (cold intolerance, fatigue, sluggishness) can have other causes, but they are the defining features of hypothyroidism.

In weight-maintenance or weight-reduction diets, with one exception, studies in which total calories are held constant have found that basal metabolism was unaffected by the carbohydrate content of the diet.

The Argument from Lack of Symptoms

Carbohydrate-restriction results in a hormonal profile that is identical to that of mild low T3 syndrome: TSH and T4 normal, T3 low. (Reverse T3 may be high or normal.)

Mild low T3 syndrome is not associated with any overt symptoms of hypothyroidism. In the words of one researcher, “Patients who have only a drop in serum T3, representing the mildest form of NTIS, do not show clinical signs of hypothyroidism, nor has it been shown that this decrease in serum T3 has an adverse physiological effect on the body …”.

Occam’s Razor

One of the functions of T3 is its role, along with insulin, in metabolizing blood sugar. Other things equal, lower levels of dietary carbohydrate mean lower levels of blood sugar. The simplest and most plausible explanation for the lower levels of T3 that accompany low-carb diets is that the amount of T3 required to perform all of its functions is now less.

Epilogue

There are anecdotal reports of symptoms of hypothyroidism in those following a low-carb diet that were improved by the isocaloric addition of dietary carbohydrate.

The preponderance of clinical evidence suggests that their symptoms were caused by too few calories or a pre-existing thyroid condition. Attempting to treat the symptoms of hypothyroidism by adding carbohydrate to the diet might offer some improvement via the placebo effect, but it will not address the underlying cause and, more importantly, will delay treatment.

Notes

“There’s no shortage of evidence …”: Refs. 1-12.

“A (Very) Brief Introduction to Thyroid Hormones”: Ref. 13.

“Hypthyroidism(s)”: Ref. 14, 15.

“Low T3 syndrome, also known as…”: Ref. 16.

“Whether low T3 syndrome is adaptive…”: Ref. 17.

“Low T3 syndrome varies in severity…”: Ref. 18.

“Mild low T3 syndrome has no overt symptoms…”: Ref. 17.

“Low T3 syndrome can exacerbate…”: Ref. 19.

“Ketogenic diets that restrict …”: Ref. 23.

“… are not among them …”: Ref. 24.

“In weight-maintenance or weight-reduction diets …”: Refs. 7, 11, 25-30.

“… with one exception…”: Ref. 8. Hendler, et al, found that adding table sugar to a weight-reducing diet increased basal metabolism, and suggested that weight-loss might be enhanced in this way. Given the known effect of refined carbohydrate on norepinephrine, and the effect of norepinephrine on basal metabolism, however, it’s impossible to conclude from this study that the elevated metabolism was caused by the increase in T3.

“Carbohydrate-restriction results in …”: Refs. 3, 5-7, 10-12.

“Mild low T3 syndrome is not associated with …”: Ref 17:

“One of the functions of T3 …”: Refs. 2, 31.

References

(Abstracts and links to free full text are included where available.)

1. Danforth, et al: Dietary-induced Alterations in Thyroid Hormone Metabolism during Overnutrition, Clin Invest. 1979 November; 64(5): 1336–1347

Abstract: Diet-induced alterations in thyroid hormone concentrations have been found in studies of long-term (7 mo) overfeeding in man (the Vermont Study). In these studies of weight gain in normal weight volunteers, increased calories were required to maintain weight after gain over and above that predicted from their increased size. This was associated with increased concentrations of triiodothyronine (T3). No change in the caloric requirement to maintain weight or concentrations of T3 was found after long-term (3 mo) fat overfeeding. In studies of short-term overfeeding (3 wk) the serum concentrations of T3 and its metabolic clearance were increased, resulting in a marked increase in the production rate of T3 irrespective of the composition of the diet overfed (carbohydrate 29.6 +/- 2.1 to 54.0 +/- 3.3, fat 28.2 +/- 3.7 to 49.1 +/- 3.4, and protein 31.2 +/- 2.1 to 53.2 +/- 3.7 microgram/d per 70 kg). Thyroxine [T4] production was unaltered by overfeeding (93.7 +/- 6.5 vs. 89.2 +/- 4.9 microgram/d per 70 kg). It is still speculative whether these dietary-induced alterations in thyroid hormone metabolism are responsible for the simultaneously increased expenditure of energy in these subjects and therefore might represent an important physiological adaptation in times of caloric affluence. During the weight-maintenance phases of the long-term overfeeding studies, concentrations of T3 were increased when carbohydrate was isocalorically substituted for fat in the diet. In short-term studies the peripheral concentrations of T3 and reverse T3 found during fasting were mimicked in direction, if not in degree, with equal or hypocaloric diets restricted in carbohydrate were fed. It is apparent from these studies that the caloric content as well as the composition of the diet, specifically, the carbohydrate content, can be important factors in regulating the peripheral metabolism of thyroid hormones.

2. Spaulding, et al: Effect of caloric restriction and dietary composition of serum T3 and reverse T3 in man, Journal of Clinical Endocrinology & Metabolism, Jan, 1976; 42 (1): 197–200

Abstract: To evaluate the effect of caloric restriction and dietary composition on circulating T3 and rT3 obese subjects were studied after 7-18 days of total fasting and while on randomized hypocaloric diets (800 kcal) in which carbohydrate content was varied to provide from 0 to 100% calories. As anticipated, total fasting resulted in a 53% reduction in serum T3 in association with reciprocal 58% increase in rT3. Subjects receiving the no-carbohydrate hypocaloric diets for two weeks demonstrated a similar 47% decline in serum T3 but there was no significant change in rT3 with time. In contrast, the same subjects receiving isocaloric diets containing at least 50 g of carbohydrate showed no significant changes in either T3 or rT3 concentration. The decline in serum T3 during the no-carbohydrate diet correlated significantly with blood glucose and ketones but there was no correlation with insulin or glucagon. We conclude that dietary carbohydrate is an important regulatory factor in T3 production in man. In contrast, rT3 concentration is not significantly affected by changes in dietary carbohydrate. Our data suggest that the rise in serum rT3 during starvation may be related to more severe caloric restriction than that caused by the 800 kcal diet.

3. Davidson, et al: Effect of carbohydrate and noncarbohydrate sources of calories on plasma 3,5,3′-triiodothyronine concentrations in man, Journal of Clinical Endocrinology & Metabolism, Apr, 1979; 48 (4): 577–581.

Abstract: To evaluate the effect of changes in dietary carbohydrate (CHO) and excessive caloric consumption on circulating thyroid hormone levels, six normal weight subjects were fed five separate diets: three isocaloric diets with 20%, 40%, or 80% CHO and two hypercaloric (+2000 calories) diets with 20% or 40% CHO for 5 days each as outpatients. T4, T3, and rT3 concentrations were measured in plasma samples collected on the morning of the sixth day. At least 1 week of the subjects’ usual diets intervened between each experimental diet.

Mean T4 and rT3 levels were similar after all diets. Pair-wise comparisons among all five diets revealed significantly (P <;;;;;;;;;;;;;;;;;;;; 0.005) increased T3 concentrations after both hypercaloric diets compared to the iso-20 and iso-40 diets, and after the iso-80 compared to the iso-20 diet. A multiple regression analysis of the data revealed the highest correlation of T3 levels with total calories (r = 0.68; P <;;;;;;;;;;;;;;;;;;;; 0.001) rather than with the intake of CHO (r = 0.46; P <;;;;;;;;;;;;;;;;;;;; 0.025), fat (r = 0.49; P <;;;;;;;;;;;;;;;;;;;; 0.02), or protein (r = 0.30; P = NS). A repeated measures analysis of variance of the data revealed that over a daily caloric range of 2100-4100 calories, increasing CHO intake between 204-408 g did not influence T:t levels. However, over this same range of CHO intake, increasing calories between 2100-4100 was associated with increased T3 concentrations. Furthermore, this caloric effect on T3 levels was independent of CHO intake.

These data suggest that: 1) non-CHO as well as CHO sources are important modulators of plasma T3 concentrations in man; and 2) the influence of non-CHO calories may actually be more pronounced than that of CHO when at least a normal amount (-200 g) of CHO is ingested.

4. Azizi F.: Effect of dietary composition on fasting induced changes in serum thyroid hormones and thyrotropin.Metabolism, 1978; 27: 935-942.

“Azizi (17) using a 800 kcal mixed or exclusively carbohydrate refeeding diet over a 4-day period reported that T3 returned to baseline, while it continued to decrease when the diet contained only protein or fat.” (Cited in Serog, et al, 1982.)

5. Serog, et al: Effects of slimming and composition of diets on V02 and thyroid hormones in healthy subjects, American Journal of Clinical Nutrition, Jan 1982; 35: 24-35

Abstract: Oxygen consumption and plasma thyroid hormone concentrations are modified by both low- and high-calorie diets. It has been suggested that the trigger may be changes in weight (“adipostatic” hypothesis involving the difference between the actual weight and the “set point”) or changes in amount of carbohydrate in the diet (“carbohydrate” hypothesis”). Two experiments were performed in order to test both hypotheses. Fourteen young healthy volunteers were studied: I) at their spontaneous stable weight; 2) while losing weight rapidly on a calorically restricted diet; 3) and then at their stable new weight when consuming a refeeding diet. The calorie restricted diet resulted in decrease of c’O2, and T3, and an increase of rT3; the refeeding diet resulted in values of ı‘O2, T3, and rT3 intermediate between those of the spontaneous diet and those ıf the restricted diet. Another group of nine subjects were studied at their spontaneous caloric and proteic levels, comparing a diet containing only protein and carbohydrate with a diet containing only protein and fat. During the low carbohydrate diet rT3 increased and T3 decreased but they remained unchanged during the carbohydrate-rich diet. Thus neither the adipostatic hypothesis nor the carbohydrate hypothesis is sufficient alone to explain the observed changes in serum T3 and rT3.

From the full text: ” …VO2 [oxygen consumption] does not vary significantly even when T3 and rT3 vary.”

6. Fery F, et al.: Hormonal and metabolic changes induced by an isocaloric isoproteinic ketogenic diet in healthy subjects. Diabetes & Metabolism, Dec 1982; 8 (4): 299-305

The effects of a 4-day isocaloric isoprotenic dietary replacement of carbohydrate by fats were studied in six healthy subjects, the experimental diet being preceded and followed by a 3-day period of balanced diet. During the ketogenic regimen, the concentrations of fat derived substrates (free fatty acids, glycerol and 3-hydroxybutyrate) rose significantly and glucose levels decreased by 16.5 +/- 3.2% (mean +/- SEM). The hormonal pattern switched towards a catabolic mode with a fall in insulin levels (-44.0 +/- 6.3%) and a rise in glucagon concentration (+39.0 +/- 10.4%). A significant fall in triiodothyronine and rise in reverse triiodothyronine were observed, while thyroxine levels remained unchanged. The average levels of the most important gluconeogenic amino acids (alanine, glutamine, glycine, serine and threonine) were reduced by 8-34% while those of the branched chain amino acids increased by more than 50%. Since these changes reproduce those observed after a few days of total fasting, we suggest that it is the carbohydrate restriction itself which is responsible for the metabolic and hormonal adaptations of brief fasting.

7. Mathieson RA, et al. The effect of varying carbohydrate content of a very-low-caloric diet on resting metabolic rate and thyroid hormones. Metabolism, May, 1986; 35 (5): 394-398

Twelve obese women were studied to determine the effects of the combination of an aerobic exercise program with either a high carbohydrate (HC) very-low-caloric diet (VLCD) or a low carbohydrate (LC) VLCD diet on resting metabolic rate (RMR), serum thyroxine (T4), 3,5,3′-triiodothyronine (T3), and 3,5,3′-triiodothyronine (rT3). The response of these parameters was also examined when subjects switched from the VLCD to a mixed hypocaloric diet. Following a maintenance period, subjects consumed one of the two VLCDs for 28 days. In addition, all subjects participated in thrice weekly submaximal exercise sessions at 60% of maximal aerobic capacity. Following VLCD treatments, participants consumed a 1,000 kcal mixed diet while continuing the exercise program for one week. Measurements of RMR, T4, T3, and rT3 were made weekly. Weight decreased significantly more for LC than HC. Serum T4 was not significantly affected during the VLCD. Although serum T3 decreased during the VLCD for both groups, the decrease occurred faster and to a greater magnitude in LC (34.6% mean decrease) than HC (17.9% mean decrease). Serum rT3 increased similarly for each treatment by the first week of the VLCD. Serum T3 and rT3 of both groups returned to baseline concentrations following one week of the 1,000 kcal diet. Both groups exhibited similar progressive decreases in RMR during treatment (12.4% for LC and 20.8% for HC), but values were not significantly lower than baseline until week 3 of the VLCD. Thus, although dietary carbohydrate content had an influence on the magnitude of fall in serum T3, RMR declined similarly for both dietary treatments.

8. Hendler, et al: Sucrose substitution in prevention and reversal of the fall in metabolic rate accompanying hypocaloric diets. American Journal of Medicine, 1986; 81 (2): 280-284

Hypocaloric diets cause a fall in resting metabolic rate that interferes with weight loss. To evaluate the mechanisms underlying this phenomenon, resting metabolic rate was measured sequentially in six healthy obese women on a weight maintenance diet (more than 2,300 kilocalories), after 15 days of an 800 kilocalories carbohydrate-free diet, and after isocaloric sucrose replacement for an additional 15 days. The carbohydrate-free diet produced a 21 percent decline in resting metabolic rate (p less than 0.005) as well as a decrease in circulating triiodothyronine (41 percent, p less than 0.02) and insulin (38 percent, p less than 0.005) concentrations. Plasma norepinephrine levels also tended to decline (10 percent, 0.05 greater than p less than 0.1). However, when sucrose was substituted, resting metabolic rate rose toward baseline values even though total caloric intake was unchanged and weight loss continued. The sucrose-induced rise in resting metabolic rate was accompanied by a rise in serum triiodothyronine values, but not plasma insulin or norepinephrine concentrations. Throughout, changes in resting metabolic rate correlated with changes in serum triiodothyronine levels (r = 0.701, p less than 0.01). In four obese women, a hypocaloric sucrose diet was given at the outset for 15 days. The fall in both resting metabolic rate and triiodothyronine concentration was markedly reduced as compared with values during the carbohydrate-free diet. It is concluded that carbohydrate restriction plays an important role in mediating the fall in resting metabolic rate during hypocaloric feeding. This effect may, at least in part, be related to changes in circulating triiodothyronine levels. Incorporation of carbohydrate in diet regimens may, therefore, minimize the thermic adaptation to weight loss.

9. Burman KD, et al. Glucose modulation of alterations in serum iodothyronine concentrations induced by fasting. Metabolism, Apr, 1979; 28 (4): 291–299

10. Volek JS, et al. Body composition and hormonal responses to a carbohydrate-restricted diet. Metabolism. 2002 Jul; 51 (7): 864-870

The few studies that have examined body composition after a carbohydrate-restricted diet have reported enhanced fat loss and preservation of lean body mass in obese individuals. The role of hormones in mediating this response is unclear. We examined the effects of a 6-week carbohydrate-restricted diet on total and regional body composition and the relationships with fasting hormone concentrations. Twelve healthy normal-weight men switched from their habitual diet (48% carbohydrate) to a carbohydrate-restricted diet (8% carbohydrate) for 6 weeks and 8 men served as controls, consuming their normal diet. Subjects were encouraged to consume adequate dietary energy to maintain body mass during the intervention. Total and regional body composition and fasting blood samples were assessed at weeks 0, 3, and 6 of the experimental period. Fat mass was significantly (P <;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;or=.05) decreased (-3.4 kg) and lean body mass significantly increased (+1.1 kg) at week 6. There was a significant decrease in serum insulin (-34%), and an increase in total thyroxine (T(4)) (+11%) and the free T(4) index (+13%). Approximately 70% of the variability in fat loss on the carbohydrate-restricted diet was accounted for by the decrease in serum insulin concentrations. There were no significant changes in glucagon, total or free testosterone, sex hormone binding globulin (SHBG), insulin-like growth factor-I (IGF-I), cortisol, or triiodothyronine (T(3)) uptake, nor were there significant changes in body composition or hormones in the control group. Thus, we conclude that a carbohydrate-restricted diet resulted in a significant reduction in fat mass and a concomitant increase in lean body mass in normal-weight men, which may be partially mediated by the reduction in circulating insulin concentrations.

11. Bisschop PH, et al. Isocaloric carbohydrate deprivation induces protein catabolism despite a low T3-syndrome in healthy men. Clinical Endocrinology, 2001; 54: 75-80

Dietary carbohydrate content is a major factor determining endocrine and metabolic regulation. The aim of this study was to evaluate the relation between thyroid hormone levels and metabolic parameters during eucaloric carbohydrate deprivation. We measured thyroid hormone levels, resting energy expenditure (by indirect calorimetry) and urinary nitrogen excretion in six healthy males after 11 days of three isocaloric diets containing 15% of energy equivalents as protein and 85%, 44% and 2% as carbohydrates. In contrast to the high and intermediate carbohydrate diets, carbohydrate deprivation decreased plasma T3 values (1.78 +/- 0.09 and 1.71 +/- 0.07 vs. 1.33 +/- 0.05 nmol/l, respectively, P <;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; 0.01), whereas reverse T3, T3 uptake and free T4 levels increased simultaneously compared to the other two diets. TSH values were not different among the three diets. Although dietary carbohydrate content did not influence resting energy expenditure, carbohydrate deprivation increased urinary nitrogen excretion (10.91 +/- 0.67 and 12.79 +/- 1.14 vs. 15.89 +/- 1.10 g/24 h, respectively, P = 0.03). Eucaloric carbohydrate deprivation increases protein catabolism despite decreased plasma T3 levels. Because it has previously been shown that starvation decreases plasma T3 levels, resting energy expenditure and nitrogen excretion, these discordant endocrine and metabolic changes following carbohydrate deprivation indicate that the effects of starvation on endocrine and metabolic regulation are not merely the result of carbohydrate deprivation.

12. Otten MH, et al. The Role of Dietary Fat in Peripheral Thyroid Hormone Metabolism. Metabolism, Oct, 1980; 29 (10): 930-935 Arzneimittelforschung, 1986 Feb;36(2):262-5

Short term changes in serum 3,3′,5-triiodothyronine (T3) and 3,3’5-triiodothyronine (reverse T3, rT3) were studied in four healthy nonobese male subjects under varying but isocaloric and weight maintaining conditions. The four 1500 kcal diets tested during 72 hr, consisted of: I, 100% fat; II, 50% fat, 50% protein; III, 50% fat, 50% carbohydrate (CHO), and IV, a mixed control diet. The decrease of T3 (50%) and increase of rT3 (123%) in the all-fat diet equalled changes noted in total starvation. In diet III (750 kcal fat, 750 kcal CHO) serum T3 decreased 24% (NS) and serum rT3 rose significantly 34% (p <;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; 0.01). This change occurred in spite of the 750 kcal CHO. This amount of CHO by itself does not introduce changes in thyroid hormone levels and completely restores in refeeding models the alterations of T3 and rT3 after total starvation. The conclusion is drawn that under isocaloric conditions in man fat in high concentration itself may play an active role in inducing changes in peripheral thyroid hormone metabolism.

13. The Merck Manual for Healthcare Professionals: Overview of Thyroid Function

14. The Merck Manual for Healthcare Professionals: Hypothyroidism

15. The Mayo Clinic: Hypothyroidism Symptoms

16. The Merck Manual for Healthcare Professionals: Euthyroid Sick Syndrome

17. DeGroot, Leslie: Dangerous Dogmas in Medicine: The Nonthyroidal Illness Syndrome. Journal of Clinical Endocrinology & Metabolism January 1, 1999 vol. 84 no. 1 151-164

18. Medscape Reference: Euthyroid Sick Syndrome

19. Medscape Reference: Euthyroid Sick Syndrome, Clinical Presentation

20. Mastorakos, et al: Exercise and the stress system. Hormones (Athens). 2005 Apr-June; 4(2): 73-89

21. O’Connell, et al: Changes in serum concentrations of 3,3′,5′-triiodothyronine and 3,5,3′-triiodothyronine during prolonged moderate exercise. J Clin Endocrinol Metab. 1979 Aug;49(2):242-6.

The effect of moderate bicycle exercise (3.5 h) on peripheral thyroid hormone metabolism was studied under two conditions (with and without glucose infusion) in four normal males. Serum T3, rT3, total protein, plasma glucose, and FFA were determined. Exercise induced an increase in rT3 from 29 to 40 ng/dl (P less than 0.01), a decrease in T3 from 154 to 147 ng/dl (P less than 0.01), and an increase in T4 from 7.1 to 7.5 micrograms/dl (P less than 0.05). When glucose was infused during exercise, the changes in rT3 were blunted (P less than 0.01) and the changes in T3 and T4 were diminished. During exercise, rT3 correlated with FFA (r = 0.95) and plasma glucose (r = -0.87). When glucose was infused during exercise, these correlations decreased (r = 0.81 and -0.56, respectively). Since moderate, prolonged exercise induces a state of early or acute starvation it is concluded that the changes in peripheral thyroid hormone metabolism reported here are similar to those found in starvation. The temporal changes of rT3, FFA, and plasma glucose during exercise suggest a relationship between thyroid hormone metabolism and the uptake and utilization of FFA and glucose or the mixture of these body fuels.

22. Phinney, et al: Capacity for Moderate Exercise in Obese Subjects after Adaptation to a Hypocaloric, Ketogenic Diet. J Clin Invest. 1980 November; 66(5): 1152–1161.

23. Wirrell, Elaine: Ketogenic Ratio, Calories and Fluids: Do They Matter? Epilepsia. 2008 November; 49(Suppl 8): 17–19

24. Kang, et al: Early- and Late-Onset Complications of the Ketogenic Diet for Intractable Epilepsy Epilepsia 2004;45:1116–1123.

The most common early-onset complication was dehydration, especially in patients who started the KD with initial fasting. Gastrointestinal disturbances, such as nausea/vomiting, diarrhea, and constipation, also were frequently noted, sometimes associated with gastritis and fat intolerance. Other early-onset complications, in order of frequency, were hypertriglyceridemia, transient hyperuricemia, hypercholesterolemia, various infectious diseases, symptomatic hypoglycemia, hypoproteinemia, hypomagnesemia, repetitive hyponatremia, low concentrations of high-density lipoprotein, lipoid pneumonia due to aspiration, hepatitis, acute pancreatitis, and persistent metabolic acidosis. Late-onset complications also included osteopenia, renal stones, cardiomyopathy, secondary hypocarnitinemia, and iron-deficiency anemia. Most early- and late-onset complications were transient and successfully managed by careful follow-up and conservative strategies. However, 22 (17.1%) patients ceased the KD because of various kinds of serious complications, and 4 (3.1%) patients died during the KD, two of sepsis, one of cardiomyopathy, and one of lipoid pneumonia.

25. Leibel, et al: Energy intake required to maintain body weight is not affected by wide variation in diet composition. Am J Clin Nutr. 1992 Feb;55(2):350-5.

“Other investigators, studying subjects over shorter time periods than we used here, reported no effect on various aspects of energy expenditure (24-h expenditure, resting metabolic rate) of high- vs low-CHO diets. (See refs. 26-30)

26. Lean, et al: Metabolic effects of isoenergetic nutrient exchange over 24 hours in relation to obesity in women. Int J Obes 1988;12: 15-27.

27. Hurni, et al: Metabolic effects of a mixed and a high-carbohydrate diet in man, measured over 24 hours in a respiration chamber. Br J Nutr 1982;47:33-43.

28. McNeill, et al: Inter-individual differences in fasting nutrient oxidation and the influence ofdiet composition. Int J Obes 1988;12:455-63.

29. Abbott, et al: Energy expenditure in humans: effects of dietary fat and carbohydrate. Am JPhysiol 1990;258:E347-5 1.

30. Hill, et al: Nutrient balance in humans: effects of diet composition. Am J Clin Nutr 1991;54:lO-7.

31. Colorado State Online Textbooks: Mechanism of Action and Physiologic Effects of Thyroid Hormones

” Thyroid hormones stimulate almost all aspects of carbohydrate metabolism, including enhancement of insulin-dependent entry of glucose into cells …”

32. Loucks AB, Callister R.: Induction and prevention of low-T3 syndrome in exercising women. Am J Physiol. 1993 May;264(5 Pt 2):R924-30.

Exercise Intensity and Fat-Loss: Nothing in Moderation

It’s hard to understate the benefit of moderate-intensity exercise for weight-loss. Aerobic exercise alone can produce a modest decrease in weight, but rarely achieves clinical significance. The benefit is especially modest considering the amount of time required to achieve it. When aerobic exercise is combined with a calorie-restricted diet, the benefit is even less, and becomes smaller still as the restriction increases. Resistance exercise alone is no more likely to produce fat-loss than not.

All is not lost.

Low-volume, high-intensity interval training (HIIT) combines brief periods of all-out effort with periods of reduced effort or complete rest. It has been shown to provide the same or similar benefits as continuous aerobic exercise, plus an improvement in anaerobic fitness, with considerably less time and effort.

Because a lack of time is the reason most often given for failing to adhere to an exercise program, low-volume HIIT has generated some interest in research and the popular press as an alternative to continuous aerobic exercise. Perhaps because it has long been assumed that the effect of exercise on weight-loss is strictly a function of caloric expenditure, low-volume HIIT has received little attention as an alternative for weight-loss. The attention it has received, however, has produced some interesting results.

In one study, twenty-seven men and women aged 18-32 were divided into two groups. One group completed a 20-week program of moderate to vigorous aerobic exercise. The other group completed a 15-week program combining moderate aerobic exercise and low-volume HIIT. Subcutaneous fat was assessed by skinfold measurements. The loss of subcutaneous fat was greater in the HIIT group even though the aerobic exercise group expended roughly twice as many calories. Adjusted for energy expenditure, the loss of subcutaneous fat in the HIIT group was nine times greater than the aerobic exercise group. (Neither group lost weight, suggesting that lean mass was increased, especially in the HIIT group.)

In another study, thirty-four women aged 18-30 were divided into two exercise groups and one control group. One exercise group performed low-volume HIIT, the other moderate aerobic exercise, both for a period of 15-weeks. There was no loss of weight or fat in either the aerobic exercise group or the control group, while the HIIT group lost an average of ~6 pounds, all from fat. Also, improvements in measures of insulin sensitivity (fasting insulin, HOMA-IR) were roughly three times greater in the HIIT group compared to the aerobic group, although only fasting insulin was significantly different from the control. The energy expenditure of both exercise groups were similar, but the HIIT program required only half the time as the aerobic exercise program. Interestingly, members of the HIIT group lost fat and gained lean mass primarily in the abdomen and thighs, although total lean mass was unchanged.

Given the differences in the way we respond to moderate vs. high-intensity exercise, both in magnitude and in kind, it isn’t clear why low-volume HIIT has this effect, but it does not appear to be the number of calories expended during exercise. The dramatic reduction in measures of insulin resistance, however, raises the possibility that whatever effect exercise has on fat-loss may be the result of lower average levels of circulating insulin.

For dieters and non-dieters alike, aerobic exercise and resistance training have well-established benefits for the prevention or treatment of chronic disease and quality of life. Resistance training in particular can help preserve muscle mass and bone density. Both should be recommended for those reasons alone.

While there are additional risks associated with high-intensity exercise, especially for some groups with chronic disease, we should at least consider the possibility that low-volume HIIT might be superior to high-volume, moderate-intensity aerobic exercise for those of us engaged in an exercise program primarily for weight-loss.

Notes:

“… a moderate decrease …”: Wing: “In 6 of the 10 studies reviewed here, the differences were significant. However, in all cases [except one] the effect of exercise was very modest.” Garrow, et al: “Aerobic exercise without dietary restriction among men caused a weight loss of 3 kg in 30 weeks compared with sedentary controls, and 1.4 kg in 12 weeks among women …”. (Both cited in the ACSM Position Stand.)

“… clinical significance …”: ACSM Position Stand: “Few studies with sedentary overweight or obese individuals using PA [Physical Activity] as the only intervention result in ≥3% decreases of baseline weight.”

(Clinical significance in this case means “beneficial improvements in chronic disease risk factors”.)

“The benefit is especially modest …”: ACSM Position Stand: “… it seems that PA [Physical Activity] <150 min·wk-1 results in minimal weight loss compared to controls, PA > 150 min·wk-1 results in modest weight loss of ∼2-3 kg, and PA between 225 and 420 min·wk-1 results in 5- to 7.5-kg weight loss.

In one study cited by the ACSM Position Stand as an example of “laboratory studies generally [finding] greater levels of weight loss in response to PA” 225 minutes/week of aerobic exercise (~80% MHR) over 16 months produced an average weight loss of 11 pounds in men and no weight loss in women. (Donnelly, et al) For the men, this was a monthly return of less than one pound of weight-loss in exchange for 15 hours of exercise.

“… is combined with …”: Wing: “Only two of the 13 studies showed a statistically significant difference in the weight loss obtained in the diet plus exercise condition compared with the diet condition alone…with [one study] finding the significant difference in men only.” (Cited in the ACSM Position Stand.)

“… becomes smaller still …”: ACSM Position Stand: “When energy intake is reduced severely, diet and diet and PA [Physical Activity] groups tend to have similar results.”

“Resistance training alone …”: ACSM Position Stand: “Resistance training will not promote clinically significant weight loss.” “Neither randomized controlled … nor intervention studies without a sedentary comparison group … provide evidence for a reduction in body weight when resistance training is performed without any modification of diet. However, the studies since 1999 are equally split concerning whether resistance training will cause a loss of body fat.”

“Low-volume, high-intensity …”: In research, most often thirty-second sprints between four minute rest periods, repeated four to six times (“Wingate Protocol”).

The length and intensity of both the sprint and rest periods are infinitely variable. This allows for modifications to suit individual needs, and almost unlimited opportunities for market differentiation among trainers and gym owners. (“Thirty seconds is useless! Thirty-five seconds will make you a god!”)

“… the same or similar benefits …”: Martin J. Gibala, et al.

“… anaerobic fitness …”: Tabata I, et al.

“… considerable savings …”: Martin J. Gibala, et al: “Training time commitment over 2 weeks was ∼2.5 h for SIT [sprint interval training] and ∼10.5 h for ET [endurance training] and total training volume was ∼90% lower for SIT versus ET (∼630 versus ∼6500 kJ).”

“… the popular press …”: How 1-Minute Intervals Can Improve Your Health

“… it has long been assumed …”: Given the number of chronic physiological responses to regular exercise, not the least of which is improved insulin sensitivity, there is at least some reason to believe that this is incorrect.

“… produced some interesting results.”: Stephan H. Boutcher

“One study …”: Tremblay, et al

“In another study …”: Trapp, et al

“Given the differences …”: Marliss, Vranic; Boutcher

“… groups with chronic disease …”: Exercise-Intensity and Diabetes: HIIT Me?

Resources:

ACSM Position Stand: Appropriate Physical Activity Intervention Strategies for Weight Loss and Prevention of Weight Regain for Adults, Medicine & Science in Sports & Exercise: February 2009 – Volume 41 – Issue 2 – pp 459-471

Wing, Rena R.: Physical Activity in the treatment of the adulthood overweight and obesity: evidence and research issues, Medicine & Science in Sports & Exercise: November 1999 – Volume 31 – Issue 11 – p S547. (Cited in the ACSM Position Stand.)

Garrow JS, Summerbell CD.: Meta-analysis: effect of exercise, with or without dieting, on the body composition of overweight subjects, Eur J Clin Nutr. 1995 Jan;49(1):1-10. (Cited in the ACSM Position Stand)

Joseph E. Donnelly, et al: Effects of a 16-Month Randomized Controlled Exercise Trial on Body Weight and Composition in Young, Overweight Men and Women, Arch Intern Med. 2003;163:1343-1350. (Cited in the ACSM Position Stand)

Martin J. Gibala, et al: Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance, September 15, 2006 The Journal of Physiology, 575, 901-911.

Tabata I, et al: Effects of moderate-intensity endurance and high-intensity intermittent training on anaerobic capacity and VO2max, Med Sci Sports Exerc. 1996 Oct;28(10):1327-30.

Errol B. Marliss and Mladen Vranic: Intense Exercise Has Unique Effects on Both Insulin Release and Its Roles in Glucoregulation Implications for Diabetes, Diabetes February 2002 vol. 51 no. suppl 1 S271-S283

Stephen H. Boutcher: High-Intensity Intermittent Exercise and Fat Loss, J Obes. 2011; 2011: 868305. Published online 2010 November 24.

Tremblay A, Simoneau JA, Bouchard C.: Impact of exercise intensity on body fatness and skeletal muscle metabolism, Metabolism. 1994 Jul;43(7):814-8.

Trapp EG, Chisholm DJ, Freund J, Boutcher SH.: The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women. Int J Obes (Lond). 2008 Apr;32(4):684-91. Epub 2008 Jan 15.


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